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Value of Mean Corpuscular Volume and Mean Corpuscular Hemoglobin in Screening for ß -Thalassaemia Trait

3 July, 2014 Publications

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Background: No Abstract available.

Acta Haematol. 2006; 116: 223-5.

 

By: Mamtani M, Jawahirani A, Das K, Rughwani V, Kulkarni H[/tippy]

Predictive Performance of Anthropometric Indexes of Central Obesity for the Risk of Type 2 Diabetes

3 July, 2014 Publications

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Background: In spite of several available anthropometric indexes, the relative merit of these indexes for the prediction of type 2 diabetes remains unknown. Considering that obesity and diabetes commonly coexist as co-morbidities, our objective was to directly compare the performance of measures of central and general obesity to predict the risk of type 2 diabetes. Methods. We conducted a case-control study of type 2 diabetes on 150 cases and 150 age- and gender-matched controls. We directly compared the predictive performance of five anthropometric indexes: four related to central obesity—waist circumference (WC), waist/hip ratio (WHR), abdominal volume index (AVI) and conicity index (CI); and one related to general obesity—body mass index (BMI).We used various statistical approaches like area under (AUC) receiver-operating characteristic (ROC) curves, likelihood ratios, logistic regression and Shannon’s entropy to compare the performance of the indexes in the study sample as well as bootstrapped samples. Results. WC had the highest overall predictive accuracy that was gender insensitive (AUC 0.77 in males and 0.74 in females); a comparable information content as that of AVI (Shannon’s entropy  1.81 for WC and 1.84 for AVI) and was a better predictor of the risk of type 2 diabetes than all the remaining indexes. WC also correlated strongly with the biochemical markers of diabetes like blood sugar and lipid profile. Conclusions. WC is a simple, non-invasive and accurate predictor of the risk of type 2 diabetes that can potentially be used in screening programs in developing countries.
Arch Med Res. 2005; 36: 581-9.

 

By: Mamtani MR, Kulkarni HR

Platelet distribution width (PDW) is increased in vaso-occlusive crisis in sickle cell disease.

3 July, 2014 Publications

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Background: Considering the multigenic and multifactorial nature of the disease, we argue that a generalized bone marrow hyperplasia—and not merely erythroid hyperplasia—will occur in sickle cell disease. Consequently, we expect the hematological parameters to depict erythroid, myeloid as well as megakaryocyte hyperplasia. In the light of this expectation, we hypothesized that platelet distribution width (PDW) will increase in sickle cell disease. Here, we report the results from a cross-sectional study of 216 children admitted with complaints suggestive of vaso-occlusive crisis. We observed a strong association between PDW and sickle cell disease as compared to children who had HbAA genotype. Our findings bridge previous inconsistencies relating to the role of platelets in sickle cell disease. Implications of this finding are discussed. Ann Hematol. 2004;83:331-5.

 

By: Amin MA, Amin AP, Kulkarni HR